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Antioxidant Defense Enzymatic The major enzymatic antioxidants: Superoxide Dismutase (SOD) Converts O HO + O Located in cytosol (SOD1) and mitochondria (SOD2)

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Additionally, ROS activate pro-apoptotic signaling molecules such as apoptosis signal-regulating kinase 1 (ASK1), c-Jun N-terminal kinase (JNK), and p38 [37]