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This has begun to influence international guidelines on the selection of patients for implantable cardioverter defibrillators (ICDs) that recommend lower thresholds for such devices in patients with LMNA, FLNC, PLN or RBM20 variants and other high-risk features beyond LVEF (Zeppenfeld et al., Reference Zeppenfeld, Tfelt-Hansen, de Riva, Winkel, Behr, Blom, Charron, Corrado, Dagres, de Chillou, Eckardt, Friede, Haugaa, Hocini, Lambiase, Marijon, Merino, Peichl, Priori, Reichlin, Schulz-Menger, Sticherling, Tzeis, Verstrael, Volterrani and Group2022)