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Description

The lone pair (LP(1)) on the oxygen atom of GHB (O 71 ) donates into the * anti-bonding orbital of the C 69 -O 70 bond within GHB itself, with a high second-order perturbation energy (E 2 ) of 30.77 kcal.mol 1

The risk is highest when you first start Mounjaro or when you increase your dose which is why you need to take extra precautions during these times

PMID: 59 OliveriV

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