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Biochim Biophys Acta 139(2):319327 Nunes T, Rocha JF, Vaz-da-Silva M, Igreja B, Wright LC, Falco A, Almeida L, Soares-da-Silva P (2010) Safety, tolerability, and pharmacokinetics of etamicastat, a novel dopamine--hydroxylase inhibitor, in a rising multiple-dose study in young healthy subjects

For instance, oral administration might be subject to first-pass metabolism in the liver, reducing the effective concentration of 5-Amino-1MQ compared to a direct subcutaneous injection

324 MyD88, an adapter protein that consists of an N-terminal death domain and a C-terminal Toll/IL-1 receptor (TIR) domain, mediates the activation of NF-B and MAPK pathways