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In contrast to TMX-treated rats, the protective group treated with LC showed a significant decrease in AchE (51%) and MAO (25%) activity and a significant increase in Ach, DA, and 5-HT levels (117, 84, and 37%, respectively)

Overall, these limitations might encourage the search of different approaches, which might combine a more favorable compliance and safety, with acceptable efficacy and with more affordable treatment regimens, and might be therefore particularly suited in a minority of patients experiencing one or more hindrances to PDE5i treatment

Epilepsia 1993;34:184-7

Major adaptations of prostate cancer to the inhibition of AR signaling are counterbalanced enhancement of AR signaling through AR overexpression, gene amplification, activating mutations, and expression of ligand-independent variants (10, 11)