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Since peripheral arteries have relatively more smooth muscle cells than collagen fibers [48], brachial PWV and leg PWV are more responsive to NO-mediated vasodilation than the aorta [50,51]

In literature there were a several animal model studies have demonstrated that ebselen reduces oxidative stress in ischemia-reperfusion in heart and that it exhibits promising neuroprotective effect in brain

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Additionally, the expression of mRNA and protein for both 25-hydroxylases (CYP2R1 and CYP27A1), 1--hydroxylase (CYP27B1), and VDR were downregulated, but that of 24-hydroxylase (CYP24A1) was significantly upregulated in the liver of HFD-fed mice compared to those in controls (Fig