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Cycle structure Most protocols cap on-time at 4-6 weeks with at least equal off-time before any subsequent cycle

Allameh, A., Niayesh-Mehr, R., Aliarab, A., Sebastiani, G

A reduced initial dose should be considered for patients known to be homozygous for the UGT1A1*28 allele However, the precise dose reduction in this patient population is not known Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Other polymorphisms of UGT due to random genetic differences have been reported, but only a few have suggested to influence drug metabolism in the clinic

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How Often Will You Need B12 Injections