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Briefly, one electron reduces CYP through the NADPH/NADP + system and a non-heme iron protein

Recently, a hybrid model (cuprizone autoimmune encephalitis or CAE) combining the myelin-toxic effects of cuprizone (Zirngibl et al., 2022) together with an immune stimulation identical to EAE but without extrinsic myelin peptides, provided proof-of-principle for the notion that a primary biochemical dysmyelination can result in a very typical inflammatory demyelinating white matter lesion in an immune-stimulated host (Caprariello et al., 2018)

Mar 2024;19(2):275-293.doi:10.1007/s11739-023-03374-w

This molecule is involved in the formation of new blood vessels and was first seen upregulated in an aggressive form of glioblastoma [1]