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GCS-HC also has NFB binding sites that are essential for GCS expression in some, but not all cell types (71)

Left ventricular alterations and end-stage renal disease

Additional caution or monitoring may be appropriate in research settings involving: Active cancer- or tumor-related research models, where antioxidant-related pathways may influence cellular-response or treatment-response mechanisms Severe asthma or hypersensitivity-prone research models, as rare sensitivity-related observations have been reported in some experimental contexts Sulfur-sensitive research models, due to Glutathione containing a thiol (sulfur-containing) group Complex hepatic-function or detoxification-related investigations, where antioxidant modulation may influence oxidative-stress or liver-related biomarkers Research conditions, research amounts, protocol duration, administration frequency, and concurrent compounds may influence tolerability observations across experimental settings

Detoxification of the Body Glutathione also plays a key role in detoxifying the liver and other organs

10.7554/eLife.85338 217 YamamotoA.SlyP