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American Journal of Physiology-Gastrointestinal and Live Physiology

doi: 10.1016/j.jalz.2016.12.001 226

The LD control group was particularly distinct from the other groups in the unweighted UniFrac and BrayCurtis dissimilarity analyses plots, suggesting that animals exposed to the same diet at an early age in life diet develop similar microbiome profiles that persist even after an acute change in diet

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Treatment with PARP inhibitors or deletion of PARP1 in mice fed a high-fat diet increased NAD + levels, improved SIRT1 activity and rescued mitochondrial function, thereby protecting the obese mice from insulin resistance [52,53,54]