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While FFAs have acute effects on insulin secretion, there is overall less evidence that alone they impair -cell survival in acute in vitro culture settings

Insulin suppression of lipolysis includes the hydrolytic cleavage of triglycerides, resulting in the generation of fatty acids and glycerol

The cytosolic p53 inhibits the formation of autophagic vacuoles 68 by interaction with FIP200 (FAK (focal adhesion kinase) family kinase-interacting protein of 200 kDa), whereas nuclear p53 acts as a transcriptional factor of genes implied in autophagy regulation