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To evaluate the role of endosomal membrane leakiness on the escape of nanoparticles, calcein was incorporated into endosomes as a marker to study endosome integrity

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1) and suggest robust and active maintenance of the cytosolic NADP redox state even under severe oxidative challenge, which is in stark contrast to previous observations of a highly volatile cytosolic NAD redox state as monitored by Peredox 13,23