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10.1095/biolreprod66.1.185 24 FedeleD.BortolottiA.CoscelliC.SanteusanioF.ChatenoudL.ColliE.et al (2000)

BAC water is strongly preferred for this reason

Patients typically exhibit heightened sensitivity to nociceptive stimuli in the CNS, which has been liked to elevated levels of excitatory neurotransmitters, such as glutamate and substance P, and reduced levels of inhibitory neurotransmitters, including serotonin and noradrenaline