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A summary of the in vivo models comprehensive of the main advantages and disadvantages and the principal application in CF research is reported in Supplementary Table S1

Mitochondrial dysfunction is associated with a wide range of diseases, such as neurodegenerative diseases, diabetes, age-related macular degeneration, and cancer

Mechanistically, MOTS-c triggers activation of the cellular energy sensor AMPK (5 AMP-activated protein kinase), which in turn enhances glucose uptake and utilization in cells