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10.1038/s41598-018-34970-y Sci Rep

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Because neither LDs nor mitochondria integrate into the classical vesicular transport pathways, non-vesicular lipid transfer between them and with the ER relies on membrane contact sites (MCS), zones of close apposition between organelles without membrane fusion (Scorrano et al

GP-Activity and kinetics were measured at 13 mM, 10 mM e 7 mM GSH

For example, by decreasing the affinity of a T cell receptor for an antigen (which a TCR binds in conjunction with an MHC molecule, i.e., the MHC "presents" the antigen to the TCR), the methods of the invention can generate a non-autoreactive variant of an autoreactive TCR