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This metabolic transformation also results in reduced affinity of the compound for its cellular target

While no official weight-based protocol exists for retatrutide, the pharmacological principle is straightforward: a larger body distributes the same dose across more tissue, resulting in lower effective tissue concentration

TUNEL Assay To assess tubular cell death, TUNEL assay was used on kidney section embedded in paraffin according to the products protocols (Roche, Basel, Switzerland)