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Therefore, in one person, it may trigger excess histamine release, causing the symptoms of histamine intolerance, while in another person, it may not cause any symptoms

Tiredness may result from multiple factors including direct medication effects, inadequate caloric or nutritional intake due to reduced appetite, dehydration from gastrointestinal side effects, metabolic adaptation to weight loss, and blood sugar fluctuations in patients taking diabetes medications

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NNMT is highly expressed in the white adipose tissue of individuals with obesity and diabetes, where it acts as a "metabolic brake," slowing down the rate at which cells burn energy

Semaglutide for cardiovascular event reduction in people with overweight or obesity: SELECT study baseline characteristics