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5f) and 100% of the mice survived for 12 weeks following challenge (Fig

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A 2015 rabbit osteoarthritis model found that intra-articular injection of AOD-9604, particularly combined with hyaluronic acid, improved cartilage integrity and reduced joint degradation

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and (3) aMD5 dimerized by the longest PEG11 linker (aMD5-PEG11) showed the highest activity, whereas the others were poor agonists (Fig