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Instead, these variants are more likely to engage in heterotypic interactions with cellular proteins and membrane organelles, which may explain why Shahmoradian et al

identified that DHODH cooperates with GPX4 to suppress ferroptosis in mitochondrial membranes

Mast Cell Activation Syndrome (MCAS) is a complex and often misunderstood condition

Dopaminergic neurons in the SN are particularly sensitive to oxidative stress (Szirki et al., 1998) due to their elevated levels of pro-oxidant iron, which facilitates ROS production by reducing oxygen, and their low levels of glutathione, a crucial antioxidant in cellular metabolism (Sian-Hlsmann et al., 2011)