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Due to their similar structures, both hCG and LH bind to the same LHCGR receptor on Leydig cells, but hCG does so with greater affinity, preferentially inducing cAMP and increasing intracellular Ca, upregulating genes that code steroidogenic enzymes

Hypo methylation (methylation decreases with age) is seen in hepatocellular carcinoma, breast cancer, lung cancer, nasopharyngeal cancer, smooth muscle sarcoma, and neuroendocrine tumor

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