glutathione peroxidases peroxidase 1 Insights into the Role of

These include seven positively regulated cuproptosis genes: ferredoxin1 (FDX1), lipoic acid synthase (LAIS), fatty acid transferase 1 (LIPT1), dihydrolipoicenamide dehydrogenase (DLD), dihydrolipoic acid transacetylase (DLAT), pyruvate dehydrogenase E1-alpha subunit (PDHA1), pyruvate dehydrogenase E1- subunit (PDHB) and three negatively regulated genes: metal-regulated transcription factor 1 (MTF1), glutaminase (GLS), and cell cycle protein-dependent kinase inhibitor 2A (CDKN2A) (see Table 1 below) ( Figure 2 )

In some cases the phenotype is linked to mislocalization of the pigments to the cytoplasm 29 or vesicle-like structures 19,30

49th ed

& Leonarduzzi, G

10.1038/s41586-019-1705-2 5 BesserE.GelfandA.ProcacciaS.BermanP.MeiriD