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Notably 16 , devoid of a macrocyclic ring system in the N-terminal is not selective and inhibits both IRAP and AP-N activity, suggesting that introduction of proper conformational constrains in the N-terminal by macrocyclization improves selectivity (Axn et al., 2007)

This healing effect is observed in various models of corneal injury, including perforating corneal incisions

A damaged seal, suspected contamination, or questionable sterility

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