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Delivery of multiple factors, with tight temporal control over factor release has been shown to induce formation of more mature vasculature than delivery of a single factor

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Very long chain (C22C24) ceramides are synthesized by ceramide synthase 2 (CerS2) and a CerS2 null mouse displays hepatopathy because of depletion of C22C24 ceramides, elevation of C16-ceramide and/or elevation of sphinganine [89]