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In a mouse myocardium, acute exercise activates Nrf2 signaling via increased ROS production, which in turn, promotes the trans-activation of antioxidant genes, leading to improved cardioprotection (Muthusamy et al., 2012

In conclusion, the present study demonstrated that GCLC inhibition induces ferroptosis in cancer cells, and low glutathione tumor levels may be used as a sensitivity marker for GCLC inhibitors