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Over-supplementation without need can cause interactions with other nutrients or mild digestive issues

J leukocyte Biol (2009) 86(3):50512

Aesthetically over-injection of cheeks can sometimes make temples look hollow even if they are not, but Botox isnt causing the fat or muscle in the temples to prematurely wane

After an initial loading regimen of 1mg three times weekly for two weeks, maintenance therapy is typically 1mg every three months for life in conditions like pernicious anaemia, or every two months if neurological involvement was present

However, megadosing (taking excessive amounts of vitamin B12) may lead to some negative side effects