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Biomechanical studies using human motion segments have been shown that endplate fracture can already occur with an axial force (0.5 mm/sec) of 4.5 kN depending on the spinal alignment

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Depending on the severity of a patient's functional deficiency or their specific genetic makeup, healthcare providers may recommend starting with a lower dose and gradually titrating up, monitoring for improvements in energy levels and cognitive clarity while keeping an eye out for any temporary over-methylation symptoms, such as mild anxiety or jitteriness

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