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In APP23 transgenic mice, a single intraperitoneal LPS injection (1LPS) at 3 months increases A plaque burden and total A while reducing brain IL-10

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Matters described in FDA warning letters may have been subject to subsequent interaction between FDA and the letter recipient that may have changed the regulatory status of issues discussed in the letter

It differs from a tendon origin injection

Formal SEM diagrams are given in the Supplementary Results Figs