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These distinct properties have been recognized as a brainblood tumor barrier (BBTB) (Arvanitis et al., 2014) and a lower blood flow due to tumor growth

These novel insights into the crosstalk of two major pathogenic pathways in glioblastoma may explain some of the disappointing results when targeting either pathway alone in human glioblastoma patients and inform on potential future designs on targeted pharmacological or genetic intervention

Curcumin SLN carriers were formulated using solvent evaporation by Campisi et al

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