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The role of apoptosis in the development of acute kidney injury due to cisplatin confirmed experiments in vivo with caspase-1 / mice which appeared to be resistant to the drug-induced kidney failure [87]

doi: 10.1136/gut.2007.146357

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Therefore, addition of some intermediates (such as L-aspartic acid and citric acid) can not only promote the accumulation of intracellular L-lysine, but also provides a substrate to produce sufficient ATP [100]