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Drug Targets 7, 975992

Hypoxia is particularly closely related to the RT efficacy and is the major reason for the ineffectiveness of RT, as oxygen concentration directly influences the generation of cytotoxic free radicals of radiation 32,33

Revolutionizing intervertebral disc regeneration: advances and future directions in three-dimensional bioprinting of hydrogel scaffolds

Each mediator balances tissue O 2 supply by altering vessel tone and diameter and can contribute to a long-term remodeling of vascular structure, subsequently governing organ perfusion [52]