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In vitro experiments using fibroblast cultures have demonstrated shifts in transcriptional activity related to structural proteins and regulatory enzymes involved in tissue remodeling processes[2]

Moving beyond existing summaries of lactylation mechanisms, we adopt a clinically oriented framework that integrates resistance mechanisms across radiotherapy, chemotherapy, targeted therapy, and immunotherapy, with particular emphasis on its pivotal role as a metabolic-immune hub that coordinately remodels the TME

Unfortunately, except for the function of methional, direct interactions between MSG (or umami substances) and kokumi substances as well as kokumi substances and other basic taste receptors remain poorly elucidated at the receptor and cellular levels in taste buds