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However, the rapid development of resistance due in 50% of cases to acquisition of the secondary T790M EGFR mutation greatly limits the ability of these agents to prolong patient survival [58]

) as shown in Figure 2B, significantly alleviating the oxidative stress-inflammatory cycle and restoring the homeostasis of the wound microenvironment

While its hepatic expression remains relatively unchanged in the early stages of MASLD [290, 305], miR-21 levels were significantly elevated in patients with MASLD compared to healthy controls and individuals with steatosis [312]

In addition, 3,4,5-tri- O -caffeoylquinic acid promotes hair regrowth and stimulates pigmentation via upregulating Wnt/-catenin and Endothelin Receptor B signalling pathways in McSCs [13, 218]