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The comparison is stark

doi: 10.1007/s11154-014-9301-0 121

The cardiovascular system is uniquely vulnerable to ferroptotic stress due to its high metabolic demand, elevated oxygen consumption, and dense mitochondrial networks, which together generate substantial reactive oxygen species (ROS)

This review provides an update on the most recently published treatment guidelines for pharmacologic treatment of PAH and incorporates them into a contemporary approach to the treatment of this disease