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Several techniques have been developed to overcome this challenge, including bone marrow stimulation, osteochondral autografting, autologous chondrocyte implantation, and, more recently, mesenchymal stem cell (MSC) implantation [3]

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The association of ROS with neuronal degeneration in PD is further substantiated by modeling the Parkinsonian phenotypes in animals through 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), rotenone, 1,1-dimethyl-4,4-bipyridinium dichloride (paraquat), or 6-hydroxydopamine (6-OHDA), those are known of elevate the oxygen free-radicals in the cell 18

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