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these mainly include vitamins (vitamins A, C, E and K), melatonin, coenzyme Q10 (CoQ10), uric acid, bilirubin, carotenoids, alpha-lipoic acid (ALA), glutathione (GSH) and its precursor N-acetylcysteine (NAC) [33]

Cadmium-induced toxicity is rescued by curcumin: a review

Further supporting melatonins potential impact on brain insulin, a rat study demonstrated that melatonin, upon binding to its membrane-bound receptors, can initiate intracellular pathways in the brain typically activated by insulin binding to the insulin receptor (e.g., AKT serine phosphorylation) [137]

It is naturally synthesized in the liver and found in every cell of the body

In addition, during vaso-occlusive episodes, SCD patients show distinct metabolite profiles from those at steady-state 7,8,9,10