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Administration of WSLE NE markedly improves behavioral outcomes and histopathological features compared to WSLE alone by enhancing antioxidant enzyme activity, suppressing pro-inflammatory cytokines, and downregulating neurotoxicity-associated gene expression (110)

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7.2 Translational gaps in antioxidant-based interventions Clinical evidence supporting pharmacological antioxidants such as melatonin, coenzyme Q10, N-acetylcysteine, and dietary polyphenols remains limited and heterogeneous

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