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Caspase-3, which is a type of cysteine-aspartate protease, is crucial for the apoptosis process and is frequently utilized as an apoptosis biomarker [86]

Epalrestat increases glutathione, thioredoxin, and heme oxygenase-1 by stimulating Nrf2 pathway in endothelial cells

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This T3 reduction is hypothesized to mimic the physiological response seen during fasting or marked caloric restriction, while TSH remains stable because central feedback perceives the lower T3 as an adaptive, not a pathological, state