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SCFAs attach to immune cells G-protein-coupled receptors (GPCRs), which regulates cytokine production and reduces inflammation

The cancer can also invade nerves, blood vessels, and lymphatics within the pancreas

Defects in the AR gene can prevent the normal development of both internal and external male structures in 46, XY individuals and result in androgen insensitivity syndrome, which is the partial or complete inability of cells to respond to androgens 13,101,102

Although the proposed vicious cycle remains a working hypothesis requiring further validation, understanding this interplay may help identify novel biomarkers, stratify patients by metabolic phenotype, and guide precision therapies for HF

Subsequently, Nrf2 accumulates and translocates to the nucleus, where it binds to the Antioxidant Response Element (ARE), initiating the transcription of a battery of cytoprotective genes responsible for counteracting inflammation and oxidative stress