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Thus, while IN chelation is promising for directly targeting the brain and CNS, it still requires careful consideration of formulation strategies (e.g., nanoparticle targeting or controlled-release systems) to improve site specificity, especially for drugs with a narrow therapeutic window

Only about 1% of the homocysteine filtered by the glomeruli is normally found in the urine

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Upon hypoxia, HIF-1 is stabilized and translocates to the nucleus, where it dimerizes with HIF-1, binds to target genes, and activates gene transcription