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Studies also strongly suggest that an overactive mTOR pathway drives DAMD pathology, with dysregulation in the AMPK and SIRT1/PGC-1 pathways also contributing to metabolic alterations [63,64,65]

Metabolic reprogramming Throughout the life of an organism, the immune system continually senses and responds to environmental threats, which is a relatively energy-consuming process

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doi:10.1016/j.bbabio.2012.11.014

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