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In a head-to-head open-label trial reported in February 2026, average weight loss at 84 weeks favored tirzepatide, and the sponsor noted CagriSema did not meet its prespecified non-inferiority target against tirzepatide

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5.2 Reducing the expression of VEGF Cyclical angiogenesis is critical for maintaining follicular growth, ovulation, and subsequent corpus luteum development and regression