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Nevertheless, extramedullary relapse, commonly in central nervous system, occurs in 35% of APL patients [109]

Typically permitted after 8-12 weeks with physician approval

This short form of DELE1 then binds and activates HRI, initiating the long-observed ISR transcriptional response

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(2002) Proteins 48 : 618-627 PubMed: 12211029 Search on PubMed DOI: Primary Citation Related Structures: 1K3L, 1K3O, 1K3Y PubMed Abstract: Cytosolic glutathione S-transferases (GSTs) play a critical role in xenobiotic binding and metabolism, as well as in modulation of oxidative stress