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Cell 138 , 198208 (2009)

CeO 2 NPs are known for their pseudo-enzymatic activity due to the Ce 3+ /Ce 4+ redox cycle on the surface ( 2 NPs with polymers may interfere with these active centers, potentially reducing their antioxidant and enzymatic activities

Over time, your body builds physiological toleranceyour cells become less sensitive to the same dose of medication, similar to how caffeine feels less effective after daily use

neoformans , and grx4 null mutants show impaired response to oxidative stress upon iron starvation and/or repletion 19