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Description

Thiol-containing proteins are widespread in cells

NAD+ provides substrate for sirtuins and coenzymatic support for the Krebs cycle and OXPHOS

10.1017/S000711452000210X 151

However, low concentrations of zinc are actually required by other interacting proteins of -synuclein to prevent fibrillation ( 3 Role of zinc in modulation of -synuclein fibrillation 3.1 Importance of zinc as a micronutrient in the body In nutrition, any chemical compound that is required in minute quantity (ranges between 1 and 100 mg/day in adults or constitutes 0%1% of total body weight) is considered as a trace element (Stjernswrd et al., 1996)

Mouse treatment 7- to 10-week-old WT and Gpx4 +/IEC mice received daily ferric maltol (0.4 mg, Shield Therapeutics PLC) and/or arachidonic acid (10 mg, Sigma, 10931) via oral gavage over the course of 6 days with or without -tocopherol supplementation (0.4 mg/ml, Sigma) in drinking water ad libitum