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10.1126/scitranslmed.3010473 Summary Keywords osmolytes, chemical chaperones, TMAO, betaine, choline, cardiovascular disease, liver disease Citation Ilyas A, Wijayasinghe YS, Khan I, El Samaloty NM, Adnan M, Dar TA, Poddar NK, Singh LR, Sharma H and Khan S (2022) Implications of trimethylamine N-oxide (TMAO) and Betaine in Human Health: Beyond Being Osmoprotective Compounds