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Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10)

10.1002/pbc.25348 204 ReubiJ.-C

The human body usually contains 2.5 grams of zinc distributed among different organs and cell compartments, with the majority occurring in bones and muscles (~ 80%), followed by the skin and liver (Jackson, 1989[211])