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Homocysteine theory of arteriosclerosis: development and current status

172 The second more generalized syndrome is characterized by mild hemolytic anemia, persistent metabolic acidosis presenting in the newborn period, and progressive cerebral and cerebellar degeneration

Consequently, its dysfunctionmanifesting in prevalent conditions like metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), and drug-induced liver injury (DILI)poses a severe and growing global health challenge

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Selhub J and Miller JW (1992)