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The TIRAP/MyD88-induced signaling cascade begins from the plasma membrane, and TRAM/TRIF from the endosomes (Kagan et al., 2008)

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However, despite being devoid of LDH and counterscreen activity, this peptide showed a narrow therapeutic index ( ~ 20-fold) with proliferation potencies of 1.5 and 31 M in HCT116 and Ca Ski, respectively (Fig