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Toxicology 445, 152599

Nemazanyy, I

Gonzales DA, et al

Contrary to these results, it was demonstrated that mutations IDH1 R132H or IDH2 R172K in MEF and HeLa cells induce an increase in 2HG levels that stimulate both mTORC1 and mTORC2 signaling as highlighted by enhanced phosphorylation of p70S6K, pS6 and Rictor, and Akt, respectively