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Description

All animals were housed under controlled temperature and a 12-hour lightdark cycle, with ad libitum access to food and water

Coadministration of fluconazole 100 mg PO and hydrochlorothiazide 50 mg PO for 10 days in normal volunteers (n=13) resulted in a significant increase in fluconazole AUC and Cmax compared to fluconazole given alone

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